Lipids and Lipid Derivatives
Selleck Chemical LLC Solifenacin succinate S3048-10mg
Solifenacin succinate (YM905) is a urinary antispasmodic of the antimuscarinic class
Medchemexpress LLC Zinc stearate 100g
Zinc stearate is a Zinc distearate Zinc stearate can be used as an excipient such as lubricants for tablets and capsules Pharmaceutical excipients or pharmaceutical auxiliaries refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations which can improve the stability solubility and processability of pharmaceutical preparations Pharmaceutical excipients also affect the absorption distribution metabolism and elimination (ADME) processes of co-administered drugs[1][2]
eMolecules Chem-Impex Lauric acid 5kg 603112295 34486 0 000 143-07-7 MFCD00002736 200 322 C12H24O2
Chem-Impex Lauric acid 5kg 603112295 34486 0 000 143-07-7 MFCD00002736 200 322 C12H24O2
Medchemexpress LLC Hexadecanoic acid, methyl ester | 112-39-0 | 270.45 | 1 G
Methyl palmitate is a naturally occurring fatty acid ester that acts as a potent inhibitor of IκB phosphorylation. It modulates macrophage activity to down-regulate pro-inflammatory mediators such as TNF-α and nitric oxide (NO), exhibiting anti-inflammatory and antifibrotic effects. It can inhibit LPS-induced Kupffer cells and rat peritoneal macrophages, as well as the phagocytic function of RAW cells. This compound is also antagonistic to muscarinic receptors and provides cardioprotective effects against ischemia/reperfusion injury in vivo. It is highly toxic against adult T. cinnabarinus.
- Naturally occurring fatty acid ester
- Potent inhibitor of IκB phosphorylation
- Modulates macrophage activity
- Down-regulates pro-inflammatory mediators
- Anti-inflammatory and antifibrotic effects
- Antagonistic to muscarinic receptors
- Cardioprotective effects
Medchemexpress LLC Procyanidin B2 | 29106-49-8 | 578.52 | 25 MG
Procyanidin B2 is a natural flavonoid known for its anti-cancer and antioxidant properties, making it valuable for various research applications. It is intended for research use only.
- Exhibits antiproliferative activity in MCF-7 cells.
- Inhibits NLRP3 inflammasome activation in human umbilical vein ECs (HUVECs).
- Reduces reactive oxygen species (ROS).
- Protects against cerebral ischemia-induced infarct volume and brain edema.
- Improves neurological functional outcomes and regulates blood-brain barrier permeability.
- Attenuates cerebral ischemia-induced tight junction degradation, mitochondrial depolarization, and intracellular oxidative stress.
- Increases Nrf2 activation and expression of HO-1, GSTα, and NQO1 proteins.
Cayman Chemical Betamethasone 17-valerate, Purity: ≥98%, CAS: 2152-44-5, 500 mg
A glucocorticoid with anti-inflammatory activity; inhibits the binding of the radiolabeled glucocorticoid dexamethasone to human epidermis and mouse skin (IC50s = 5 and 6 nM, respectively); topical application of a 0.12% ointment blocks increases in ear weight in a rat model of ear edema induced by croton oil
Medchemexpress LLC Mk-0812 succinate | 851916-42-2 | 99.94% | C28H40F3N3O7 | 100 MG
MK-0812 Succinate is a potent and selective CCR2 antagonist with high affinity. It completely blocks all MCP-1 mediated responses in a concentration-dependent manner. It also inhibits 125I-MCP-1 binding on isolated monocytes. The compound blocks the shape change response to exogenous MCP-1 and reduces the frequency of Ly6G-Ly6Chi monocytes in peripheral blood in vivo.
- Potent and selective CCR2 antagonist
- High affinity at CCR2
- Blocks all MCP-1 mediated responses
- Inhibits 125I-MCP-1 binding on isolated monocytes
- Reduces Ly6G-Ly6Chi monocytes in peripheral blood in vivo
eMolecules 7425-53-8 | Ethyl 4-iodobutyrate | Combi-Blocks | MFCD00045325 | 242.056 | C6H11IO2 | 98.000 | CCOC(=O)CCCI | 5g | 415497677
Ethyl 4-iodobutyrate | Combi-Blocks | 7425-53-8 | MFCD00045325 | 242.056 | C6H11IO2 | 98.000 | CCOC(=O)CCCI | 5g | 415497677
Medchemexpress LLC Resorufin butyrate 25mg | 15585-42-9 | 25 MG
Resorufin butyrate is a fluorogenic substrate used to measure triglyceride lipase and cholinesterase activity. Upon enzymatic hydrolysis the ester is converted to resorufin, which is highly fluorescent (Ex 570 nm, Em 580 nm). Supplied as a 25 mg solid for research use, it is suitable for fluorescence-based enzyme assays and assay development.
- Fluorogenic substrate for triglyceride lipases and cholinesterase.
- Generates resorufin detectable at excitation 570 nm and emission 580 nm.
- High purity (99.0%) supports reproducible assay results.
- Stable when stored sealed at -20°C; extended stability in solvent at -80°C.
- Available in multiple package sizes to support assay optimization.
Medchemexpress LLC Phorbol 12-myristate 13-acetate | 16561-29-8 | 99.8% | 616.83 | 100 MG
Phorbol 12-myristate 13-acetate (PMA), also known as TPA or Phorbol myristate acetate, is a phorbol ester. It acts as a dual SphK and protein kinase C (PKC) activator, and also functions as a NF-κB activator. PMA induces differentiation in THP-1 cells and is known to induce a pronounced inflammatory response mediated by protein kinase C (PKC), specifically by activating PLA2.
- Dual SphK and protein kinase C activator
- NF-κB activator
- Induces differentiation in THP-1 cells
- IC₅₀ for PKC is 11.7 nM (EC50)
- Inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1